×
Suggest this Article to:
TOP INDEXERS
Public Article
-
verified
Effect of Mercuric Chloride on Hepatic Phosphatases and Transaminases in Albino Rat
ISSN: 0976 - 7614
Publisher: author
Effect of Mercuric Chloride on Hepatic Phosphatases and Transaminases in Albino Rat
Indexed in
Biology and Life Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 3
Article Operation Score: 2
Article Articles Score: 3
Article Accessibility Score: 2
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-0402
Publisher: Journal Of Advanced Laboratory Research In Biology Society..
International Journal Address (IAA):
IAA.ZONE/097652527614
eISSN
:
0976 - 7614
VALID
ISSN Validator
Abstract
Mercuric chloride is a serious health hazard and produces various disorders. However, phosphatases and transaminases are marker enzymes of hepatic toxicity. Twenty four adult albino rats have taken and divided into 4 groups. Group one for acute study, while three for subacute studies with 3 rats in each. Control was also taken with similar references. Mercuric chloride gave orally administered (LD50=9.26mg/kg b.w.) by gavage tube with distilled water. Rats were autopsized at predetermined time interval to assess hepatic toxicity. Phosphatases include alkaline phosphatase and acid phosphatase while transaminases include alanine transaminase and aspartate aminotransferase. Results revealed that ALP and ACP were significantly increased after acute and subacute treatment due to the destruction of the cell membrane of lysosomes. However, AST and ALT were also increased significantly due to toxic effect of mercuric chloride on hepatic cells...
