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Involvement of HLA in Serum Beta-2 Microglobulin levels among Mumbai HIV-1 Patients
ISSN: 0976 - 7614
Publisher: author
Involvement of HLA in Serum Beta-2 Microglobulin levels among Mumbai HIV-1 Patients
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Biology and Life Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 3
Article Transparency Score: 3
Article Operation Score: 3
Article Articles Score: 3
Article Accessibility Score: 2
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International Category Code (ICC):
ICC-0402
Publisher: Journal Of Advanced Laboratory Research In Biology Society..
International Journal Address (IAA):
IAA.ZONE/097653287614
eISSN
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0976 - 7614
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Abstract
HLA allele involves along with B-2 microglobulin (B2M) and T cell receptor in host specific immune response. HLA alleles are known for its extensive polymorphism in order to accommodate the maximum of antigenic peptides. Serum beta-2 microglobulin has been reported to have a prognostic value for predicting disease progression in HIV patients. In this study, we evaluated the serum B2M levels and the HLA profile among the 124 HIV patients and 94 Normal healthy controls from Mumbai. The B2M levels were estimated by conventional ELISA technique while the HLA A and HLA B were done using PCR – SSOP molecular kits. Our results revealed that HIV patients showed increased B2M levels (88.70%) range (2.5ug/ml – 60ug/ml) compared the controls (42.55%). HLA A*11:01:01 (OR=3.25; P value 0.0015), HLA B*35:01:01 OR=3.57;P value 0.0002), HLA B*44:03:01 (OR=5.32; P value 0.0036), haplotypes HLA A*11:01:01- B*35:01:01 (OR=5.68; P value 2.47E-05), HL...
