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Behavioral alterations induced by Toxoplama gondii during different stages of infection in mice
ISSN: 2090 - 3308
Publisher: author
Behavioral alterations induced by Toxoplama gondii during different stages of infection in mice
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Biology and Life Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 3
Article Operation Score: 2
Article Articles Score: 3
Article Accessibility Score: 2
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International Category Code (ICC):
ICC-0402
Publisher: Journal Of Applied Veterinary Sciences Rabie Fayed
International Journal Address (IAA):
IAA.ZONE/209054343308
eISSN
:
2090 - 3308
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Abstract
Acute, chronic and reactivation of Toxoplasma gondii (T. gondii) infections are approximately found in 30-60% of population world-wide. T. gondii is a pathogen relevant to psychiatric disorders. We have recently found that reactivation of chronic T. gondii induced depressive-like behaviors in mice. In the present study, we aimed to illustrate the behavioral alterations in mice during acute, chronic and after reactivation of chronic T. gondii. Behavioral battery included sucrose preference and forced swim, and fear conditioning tests, and measurement of locomotor activity following T. gondii infection in mice. First, we prepared an ethogram and confirmed that specific pathogen free-BALB/c mice exhibited sickness-like behaviors during acute infection. In addition, reduced sucrose preference and increased immobility in forced swim test (putative indicators to anhedonic and despair-like behaviors, respectively) were exhibited in acute pha...
