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Methotrexate in Rheumatoid Arthritis: Effect on Blood, Liver and Renal Laboratory Parameters
ISSN: 2617 - 9482
Publisher: author
Methotrexate in Rheumatoid Arthritis: Effect on Blood, Liver and Renal Laboratory Parameters
Indexed in
Health Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 2
Article Operation Score: 2
Article Articles Score: 2
Article Accessibility Score: 2
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International Category Code (ICC):
ICC-0702
Publisher: Bahria University Medical And Dental College
International Journal Address (IAA):
IAA.ZONE/2617100659482
eISSN
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2617 - 9482
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Abstract
Objective: To evaluate the effect of Methotrexate onblood, liver and renallaboratory parameters in patients having rheumatoid arthritis. Materials and Methods : A 24-week, single-blind, interventional study was carried out on 155 consecutive patients, aged 29-70 years, diagnosed with rheumatoid arthritis. They received tablet Methotrexate, 10 mg (2.5 mg, 4 tablets) weekly, orally. Laboratory tests like hemoglobin level, total white cell and platelet counts, erythrocyte sedimentation rate, serum glutamic pyruvic transaminase and serum creatinine levels were recorded at the initial visit as well as at 6, 14 and 24 weeks follow-up visits. Results: At the end of 24 weeks hemoglobin level increased to 12.43 ± 0.92 grams per deciliter (g/dl) from a baseline of 10.76 ± 1.12 g/dl, white cell count fell to 7,142.46 ± 1332.23 per cubic mm (cmm) from 8,572 ± 1445/cmm, the ESR fell to 40.14 ±15.78 mm of Hg in 1st hour from 81.03 ±17.98 mm of Hg, ...
