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The Toxic Effects of Low Molecular Weight Components of Cow Colostrums: The Short-Term and Long-Term Effects
ISSN: 1929 - 5634
Publisher: author
The Toxic Effects of Low Molecular Weight Components of Cow Colostrums: The Short-Term and Long-Term Effects
Indexed in
Health Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 3
Article Transparency Score: 2
Article Operation Score: 3
Article Articles Score: 2
Article Accessibility Score: 3
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International Category Code (ICC):
ICC-0702
Publisher: Lifescience Global Inc.
International Journal Address (IAA):
IAA.ZONE/1929107505634
eISSN
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1929 - 5634
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Abstract
Background: Low-molecular components of colostrum (LMWCC) have a pronounced biological activity. We investigated the effect of different doses of LMWCC (0.01, 0.1, 1 and 5 g/100 g of body weight) on the behavior, dynamics of growth, acute and chronic toxicity, as well as the relative weight of the liver, spleen and kidneys of the experimental animals. Methods: We used 100 3-month male rats in the experiment. All animals were divided into 5 groups of 20 animals in each group, LMWCC was administered per os, and the control group received sterile water. Results: LMWCC revealed no pirogenic effect in a wide diapason of doses (0,01-5 g/100 g of animal mass). Immediately after the LMWCC administration the short-time decrease in the motion activity was observed. The low doses of LMWCC induced diarrhea in 10-20 % of of animals, the super-large dose – in 75% of animals. The acute toxicity of LMWCC (death of 15 % of animals) was detected only i...
