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Wade A. Weber, Max J. Tallman, Thomas J. Blom, Jennifer D. Schurdak, L. Rodrigo Patino, Robert K. McNamara
ISSN: 1929 - 5634
Publisher: author
Wade A. Weber, Max J. Tallman, Thomas J. Blom, Jennifer D. Schurdak, L. Rodrigo Patino, Robert K. McNamara
Indexed in
Health Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 2
Article Operation Score: 3
Article Articles Score: 2
Article Accessibility Score: 3
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-0702
Publisher: Lifescience Global Inc.
International Journal Address (IAA):
IAA.ZONE/1929107515634
eISSN
:
1929 - 5634
VALID
ISSN Validator
Abstract
Children with attention deficit/hyperactivity disorder (ADHD) exhibit blood docosahexaenoic acid (DHA) deficits and cortical network pathology. This neuroimaging study investigated the effects of DHA supplementation on cortical attention network integrity in medication-free children with ADHD. Children (mean age 9.6 years, n=30) with ADHD were randomized to DHA (1,200 mg/d) or placebo for 10 weeks. Blood DHA levels and ADHD symptom severity ratings were obtained from all participants (n=30). Cortical network integrity was evaluated in a subset of patients (n=20) using functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI). Erythrocyte DHA levels increased significantly in patients receiving DHA (+60%, p≤0.0001) but not placebo (-4%, p=0.77). There were no group differences in baseline-endpoint change in ADHD symptom severity scores, sustained attention performance, or voxelwise cortical activation patterns dur...
