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Caloric Restriction Diet Induces Specific Epigenotypes Associated with Life Span Extension Authors
ISSN: 1929 - 5634
Publisher: author
Caloric Restriction Diet Induces Specific Epigenotypes Associated with Life Span Extension Authors
Indexed in
Health Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 3
Article Transparency Score: 2
Article Operation Score: 2
Article Articles Score: 2
Article Accessibility Score: 2
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International Category Code (ICC):
ICC-0702
Publisher: Lifescience Global Inc.
International Journal Address (IAA):
IAA.ZONE/1929107745634
eISSN
:
1929 - 5634
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Abstract
The lifespan of Wistar rats on caloric restriction diet (CRD) is correlated with the changes in prooxidant-antioxidant balance, in the contents of triiodothyronine, and thyroxin (epigenotype characteristics). It has been shown that in a month after the moment of one-month-old rats began to receive CRD the part (up to 15 %) of experimental animals died without any apparent cause, irrespective of the degree of calorie restriction (40 %, 57 % and 60 % weight-loss). The rest of animals with 40 %, 57 % and 60 % weight-loss had longer life span in comparison with control group. The CRD-induced life-span prolongation in animals was accompanied by the induction of specific epigenotypes featured by acceleration of the electron transfer rate in electron transport chain and subsequent reduced production of reactive oxygen species and increased antioxidant activity. The activity of glutathione reductase, glutathione transferase, NADH-cytochrome C...
