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PD-L1 in Breast Cancers and its Prognostic Significance
ISSN: 2617 - 9482
Publisher: author
PD-L1 in Breast Cancers and its Prognostic Significance
Indexed in
Health Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 3
Article Transparency Score: 3
Article Operation Score: 2
Article Articles Score: 3
Article Accessibility Score: 3
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-0702
Publisher: Bahria University Medical And Dental College
International Journal Address (IAA):
IAA.ZONE/261793719482
eISSN
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2617 - 9482
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Abstract
reast cancer is the most common malignancy in females globally. Various factors are responsible for its developmentwhich include both genetic and hormonal causes. An important discovery is the role of the PD-1/PD-L1 axis in thedevelopment of cancers. The PD-1-/PD-L1 pathway plays a part in allowing tumour cells escape from the host’s immuneresponse and hence permits the proliferation of tumour cells. PD-L1 expression has been observed in various breast cancersat distinct levels such as in tissues and in blood. Different methods have been utilized for its detection includingimmunohistochemistry, RNA sequencing and ELISA, amongst others. The results have been conflicting regarding theexpression of PD-L1 and the prognosis of breast cancer based on parameters such as overall survival and disease freesurvival. Different immunotherapies have also emerged as a new modality to treat breast cancer. This review intends toexplore the prognostic ...
