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Impeding Minocycline Induced Hyperpigmentation by Pomegranate Extractingthe Epidermis of Guinea Pig
ISSN: 2617 - 9482
Publisher: author
Impeding Minocycline Induced Hyperpigmentation by Pomegranate Extractingthe Epidermis of Guinea Pig
Indexed in
Health Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 3
Article Operation Score: 3
Article Articles Score: 3
Article Accessibility Score: 3
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International Category Code (ICC):
ICC-0702
Publisher: Bahria University Medical And Dental College
International Journal Address (IAA):
IAA.ZONE/261797389482
eISSN
:
2617 - 9482
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Abstract
Objective: This study was planned over the hypothesis that pomegranate extract rich in ellagic acid used with minocyclinecould decrease its adverse effect and prolong its therapeutic use and efficacy.Study design and Setting: This experimental study was done in the department of anatomy, Basic Medical SciencesInstitute, Jinnah Postgraduate Medical Center, Karachi,Methodology: We acquired 40 guinea pigs (male, adult, 450 – 550 gm), randomly divided them into 4 groups.Group Breceived 0.0003mg/g bodyweight of minocycline only, group C was given 0.0003mg/g bodyweight of minocycline with0.4mg/g bodyweight of pomegranate, group D was given 0.4mg/g bodyweight pomegranate only; with keeping group Awith no intervention at laboratory diet for 8 weeks. After the experimental period, the animals were sacrificed, H & E andDOPA-OXIDASE staining was done on harvested skin tissues for morphometric observations under light microscopy.Results: The resu...
