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Drug Induced Hepatotoxicity – An Ongoing Challenge
ISSN: 2617 - 9482
Publisher: author
Drug Induced Hepatotoxicity – An Ongoing Challenge
Indexed in
Health Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 3
Article Transparency Score: 3
Article Operation Score: 3
Article Articles Score: 3
Article Accessibility Score: 2
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International Category Code (ICC):
ICC-0702
Publisher: Bahria University Medical And Dental College
International Journal Address (IAA):
IAA.ZONE/261797559482
eISSN
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2617 - 9482
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Abstract
Drug induced liver injury is one of the main factor of liver failure and acute liver damage world wide with high incidencein western countries. Liver injury can be intrinsic (dose dependant) or idiosyncratic (dose independent). However idiosyncratictype is considered to be mainly responsible for drug induced liver damage. Binding of reactive metabolites of drugs totissue proteins and oxidative stress is the possible cellular mechanism involved in this process. Moreover, some antibiotics,anti-epileptics, nonsteroidal anti-inflammatory drugs etc are more likely to induce liver damage in high risks groups thatincludes females, elderly and obese people. HLA halotype and variation in protein expression also plays an important rolein this context. Various studies are available regarding clinical features, histopathological features, diagnosis and managementrelated to antibiotics and acetaminophen induced liver damage. N acetylcysteine is co...
