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Comparative Analysis of The Effects of Short-Term Metformin and Metformin-Insulin Combination on the Liver in Diabetes...
ISSN: 2617 - 9482
Publisher: author
Comparative Analysis of The Effects of Short-Term Metformin and Metformin-Insulin Combination on the Liver in Diabetes...
Indexed in
Health Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 3
Article Transparency Score: 2
Article Operation Score: 3
Article Articles Score: 2
Article Accessibility Score: 2
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-0702
Publisher: Bahria University Medical And Dental College
International Journal Address (IAA):
IAA.ZONE/261797909482
eISSN
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2617 - 9482
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Abstract
Objective: To compare the effects of drugs (Metformin and combination) on weight, size and volume of liver in diabeticrats.Study Design and Setting: This was an experimental comparative studyconducted at Institute of Bio Medical Sciences(IBMS), Dow University of Health Sciences (DUHS), Ojha Campus, Karachi.Methodology: The study was conducted on 40 albino wistar rats. Diabetic rats (n=20) were grouped into 2. One groupwas treated with metformin (n=10)while the other group with insulin-metformin combination (n=10) for 4 weeks. All thetreated groups were compared with untreated diabetic killed (n=10). After a short period of 4 weeks, all the rats weresacrificed. Livers were isolated, weighed and grossly observed for significant changes. Absolute and mean percent liverweights as well as liver volumeof all rats were calculated.Results: Data was analyzed by using GraphPad Prism version 5.0.Data for absolute/percent liver weight and liver v...
