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role of Tobacco Metabolism in the Causation of OralSquamous Cell Carcinoma in a High-Incidence Areaof South Asia
ISSN: 2617 - 9482
Publisher: author
role of Tobacco Metabolism in the Causation of OralSquamous Cell Carcinoma in a High-Incidence Areaof South Asia
Indexed in
Health Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 2
Article Operation Score: 2
Article Articles Score: 3
Article Accessibility Score: 2
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-0702
Publisher: Bahria University Medical And Dental College
International Journal Address (IAA):
IAA.ZONE/261799759482
eISSN
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2617 - 9482
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Abstract
Objective: To establish the association between CYP1A1MspIpolymorphism, tobacco-habit and oral cancer.Methodology:150 Oral squamous cell carcinoma (OSCC) and 108 controls were enrolled, comprising of individuals withoutand with tobacco habits which match in frequency and duration with patients. Study subjects were divided into four groups,namely: exclusive chewers, exclusive smokers, mixed-habit and no habit. Lifetime tobacco exposure was calculated as chewingand smoking index. After age adjustment, 140 OSCC cases and 90 controls were subjected to genetic analysis. White bloodcells were used for DNA isolation while CYP1A1 MspI polymorphism was detected with the PCR-RFLP technique. Threepolymorphisms were tested namely wild type, heterozygous variant and homozygous variants. Odds Ratios (ORs) were calculatedwhile the precision of ORs was adjusted by 95% confidence interval (CI). The risk was determined by binary logistic regressionmode...
