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Mechanism of Action, Kinetics and a Bioactive Metabolites AM404 of Paracetamol
ISSN: 2582 - 6751
Publisher: author
Mechanism of Action, Kinetics and a Bioactive Metabolites AM404 of Paracetamol
Indexed in
Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 3
Article Operation Score: 3
Article Articles Score: 3
Article Accessibility Score: 3
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: Athenaeum Scientific Publishers
International Journal Address (IAA):
IAA.ZONE/2582117416751
eISSN
:
2582 - 6751
VALID
ISSN Validator
Abstract
Abstract Paracetamol is that the one amongst the foremost broadly speaking NSAIDS used as antipyretic and analgesic drug within the world. However, still its Mechanism of Action (MOA) is not fully recognize. The potential Mechanism of Action (MOA) of paracetamol as its antipyretic and analgesic impact was thought multiple pathway. Some action relies on the inhibition of the Cyclooxygenases (COX enzyme) and a lot of recently study show that it additionally acts on serotonergic pathways (5HT pathway). A brand new metabolic pathway of paracetamol (as a prodrug) is come back to grasp, involving the generation of a lively matter, AM404 (N-4Hydroxyphenyl-5Z, 8Z, 11Z, 14Z-eicosatetraenamide), by the (FAAH) carboxylic acid organic compound hydrolase protein within the brain, was recently known. This review describes the theoretical knowledge that show the affiliation of this metabolic pathway within the analgesic & antipyretic action of aceta...
