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c-Kit - The Novel Receptor: Physiological Roles, Downstream Signaling and Implications in Cancer
ISSN: 2582 - 6751
Publisher: author
c-Kit - The Novel Receptor: Physiological Roles, Downstream Signaling and Implications in Cancer
Indexed in
Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 2
Article Operation Score: 2
Article Articles Score: 2
Article Accessibility Score: 2
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: Athenaeum Scientific Publishers
International Journal Address (IAA):
IAA.ZONE/2582117796751
eISSN
:
2582 - 6751
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Abstract
The belief that adult mammalian heart lacks regenerative potential was challenged by the identification of c-kit positive Cardiac Progenitor Cells (CPCs) in the heart. SCIPIO; a phase I clinical trial; has shown that autologous c-kit positive CPCs improve cardiac function and quality of life when transplanted into ischemic heart disease patients. c-Kit is a type III receptor tyrosine kinase and a common stem cell antigen. Stem Cell Factor (SCF) is the only known ligand for c-kit. Activation of this membrane bound receptor is known to play a crucial role in many physiological processes like hematopoiesis, immune regulation, pigmentation, gametogenesis, intestinal motility, vasculogenesis, lung and brain development. Likewise, aberrant c-kit stimulation results in several pathological conditions, including tumors of the gut, blood, lung, breast, germ cells, melanocytes and mast cells. Several pro-growth, pro-survival signaling pathways ...
