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Determination of the Effect of 2,3-Dihydroxybenzoic Acid on Lipid Profile of Prostate Cancer Cells by Shotgun Lipidomi...
ISSN: 2687 - 5365
Publisher: author
Determination of the Effect of 2,3-Dihydroxybenzoic Acid on Lipid Profile of Prostate Cancer Cells by Shotgun Lipidomi...
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Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 2
Article Operation Score: 3
Article Articles Score: 2
Article Accessibility Score: 2
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International Category Code (ICC):
ICC-1702
Publisher: International Journal Of Academic Medicine And Pharmacy Ne..
International Journal Address (IAA):
IAA.ZONE/268743075365
eISSN
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2687 - 5365
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Abstract
In this study, we aimed to determine the anticancer activities of 2,3-dihydroxybenzoic acid (2,3-DHBA) against PC-3 human prostate cancer cells. In addition, the effects of 2,3-DHBA on the lipid profile of PC-3 human prostate cancer cells were also investigated by the shotgun lipidomic approach. The anticancer activity of 2,3-DHBA which is a naturally occurring type of phenolic acid on PC-3 human prostate cancer cells was determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method. In addition, the apoptotic effect of 2,3-DHBA was investigated by DAPI (4,6-diamidino-2 phenylindole) staining. Our results showed that 2,3-DHBA have an anticancer activity to PC-3 human prostate cancer cells and this effect was increased in dose and time-dependent. In addition, DAPI staining showed that apoptotic properties such as chromatin condensation and nuclear fragmentation increased in a time-dependent manner. Certain dis...
