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Determining Clinical Correleation of CALR Type 1 and CALR Type 2 Gene Mutations In Chronic Myeloproliferative Disease ...
ISSN: 2687 - 5365
Publisher: author
Determining Clinical Correleation of CALR Type 1 and CALR Type 2 Gene Mutations In Chronic Myeloproliferative Disease ...
Indexed in
Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 3
Article Operation Score: 3
Article Articles Score: 2
Article Accessibility Score: 2
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: International Journal Of Academic Medicine And Pharmacy Ne..
International Journal Address (IAA):
IAA.ZONE/268751205365
eISSN
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2687 - 5365
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Abstract
Chronic myeloproliferative diseases (CMPD) are clonal hematopoietic disorders, with cellular proliferation, where one or more of the hematopoietic cells often undergo differentiation and maturation. In the Philedelphia (Ph) (-) CMPD group, the most common ones are polistemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). In CMPD patients, CALR (Calreticulin) mutations have been identified. In this study, identification of CALR mutations in Ph (-) CMPD patients and the effects of the presence of CALR mutations on the clinical findings of patients were investigated. A total of 76 Ph (-) CMPD cases including 35 ET, 1 PMF, 4 POST-PV, 4 POST-ET MF and 32 PV were included in the study. CALR mutations were studied using DNA sequence analysis method using DNAs isolated from venous blood of patients diagnosed with CMPD. In patients with PMF, reticulin fiber increase was found higher. Splenomegaly-correlated with dis...
