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Cisplatin-Induced Nephrotoxicity in Mouse Kidney Cortical Collection Duct Cells: Protective Role of Curcumin
ISSN: 2687 - 5365
Publisher: author
Cisplatin-Induced Nephrotoxicity in Mouse Kidney Cortical Collection Duct Cells: Protective Role of Curcumin
Indexed in
Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 2
Article Operation Score: 2
Article Articles Score: 3
Article Accessibility Score: 3
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: International Journal Of Academic Medicine And Pharmacy Ne..
International Journal Address (IAA):
IAA.ZONE/268751255365
eISSN
:
2687 - 5365
VALID
ISSN Validator
Abstract
The use of Cisplatin in chemotherapeutic treatment is limited to nephrotoxicity. It is stated that cytotoxic DNA platinum inserts, platinum transport mechanisms and pro-apoptotic DNA damage are the main causes of platinum-based renal toxicity. We have discussed the oxidative mitochondrial stress and apoptosis states that occur to understand the basic mechanism of this situation. Various antioxidants have been proposed in Cisplatin (Cisp) induced nephrotoxicities. In this study, we aimed to investigate the effects of curcumin (CurC), a powerful antioxidant, against this nephrotoxicity. Groups were created as Control, Cisplatin, Curcumin and Cisp+CurC. While lipid peroxidation levels were significantly higher in Cisp groups, GSH and GSH-Px values were low. Treatment with curcumin reversed these values. Reactive oxygen species (ROS), Mitochondrial membrane depolarization, Apoptosis, caspase-3, -9 values were also significantly increased ...
