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Erlotinib and Melatonin Treatment Reduce Proliferation of the Neural Tumor Cells (SH-SY5Y) by Mediating TRPV1 Channel ...
ISSN: 2687 - 5365
Publisher: author
Erlotinib and Melatonin Treatment Reduce Proliferation of the Neural Tumor Cells (SH-SY5Y) by Mediating TRPV1 Channel ...
Indexed in
Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 3
Article Transparency Score: 2
Article Operation Score: 3
Article Articles Score: 2
Article Accessibility Score: 3
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: International Journal Of Academic Medicine And Pharmacy Ne..
International Journal Address (IAA):
IAA.ZONE/268751275365
eISSN
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2687 - 5365
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Abstract
Neuroblastoma, which is caused by the precursors of the sympathetic nervous system, is the most commonly encountered extracranial solid tumor in the pediatric age group. TRPV1 channels, which are a subchannel of the TRP channel family in the cell membrane, are channel permeable to calcium that are known to have increased expression based on increased free radicals. They were reported to lead to apoptosis based on increased amount of intracellular free calcium when they are excessively stimulated. With this study, we purposed to determine the effect levels of erlotinib and melatonin on neuroblastoma cells through TRPV1 channels. SH-SY5Y neuroblastoma cells were used in the study. The cell series were divided into 7 main groups as Control, Erlotinib (ERLT) (5 µM, 24 hours), MEL (1 mM, 24 hours), ERLT+CPZ, MEL+CPZ, ERLT+MEL and ERLT+MEL+CPZ. TRPV1 channel activation in all groups was achieved by capsaicin. The calcium signals, intracell...
