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In vitro Effects of Mesenchymal Stem Cells and Their Niches in The Inhibition of M. tuberculosis Growth
ISSN: 2687 - 5365
Publisher: author
In vitro Effects of Mesenchymal Stem Cells and Their Niches in The Inhibition of M. tuberculosis Growth
Indexed in
Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 3
Article Operation Score: 3
Article Articles Score: 2
Article Accessibility Score: 2
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: International Journal Of Academic Medicine And Pharmacy Ne..
International Journal Address (IAA):
IAA.ZONE/268771125365
eISSN
:
2687 - 5365
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Abstract
Mesenchymal stem cells (MSC) and their niches, which are the factors secreted by MSC in culture in vitro, are considered to have a balancing and also therapeutic effect in numerous diseases. The treatment of tuberculosis (TB) caused by multidrug-resistant or extensively resistant Mycobacterium tuberculosis (MTB) strains is a challenging concern and may not be achieved by conventional treatment options. In the present study, we aimed to investigate the effect of MSC and their niches on MTB growth in culture medium. Frozen adipose-derived MSC were grown in culture medium until they became confluent. MSC and their niches, which were the factors secreted in two-day medium, were used as the conditioned medium and their effects on MTB were evaluated. MTB was maintained in liquid medium until a positive growth signal appeared on the Bactec MGIT 960 device (Becton Dickinson, Sparks, MD, USA). The growth periods (in days) were recorded. In the...
