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Comparison of the Levels of Shelterin Complex in Patients with Schizophrenia with that in Healthy Individuals
ISSN: 2687 - 5365
Publisher: author
Comparison of the Levels of Shelterin Complex in Patients with Schizophrenia with that in Healthy Individuals
Indexed in
Medical Sciences
ARTICLE-FACTOR
1.3
Article Basics Score: 3
Article Transparency Score: 2
Article Operation Score: 3
Article Articles Score: 3
Article Accessibility Score: 3
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1702
Publisher: International Journal Of Academic Medicine And Pharmacy Ne..
International Journal Address (IAA):
IAA.ZONE/268771185365
eISSN
:
2687 - 5365
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ISSN Validator
Abstract
Although it is known for more than years that telomere length (TL) and telomerase enzyme (TE) activity are lower in patients with schizophrenia than in healthy individuals, no study has been conducted on the levels of shelterin complex (SC) components in patients with schizophrenia. This study was aimed at comparing the serum levels of subunits of SC which have regulatory function on TL in schizophrenia patients with those in healthy individuals. The study included 30 patients with schizophrenia treated and 30 healthy individuals. Blood samples were taken from the participants in the schizophrenia and control groups after 12 hours of fasting, and the intergroup levels of subunits [telomere repeat binding factor 1 (TRF1), telomere repeat binding factor 2 (TRF2), protection of telomere 1 (POT1), telomerase protection protein 1 (TPP1), TRF1 interaction factor 2 (TIN2) and Repressor activator protein 1 (RAP1)] of SC were compared. At the ...
