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Osteoblast Behavior on Silicon and Porous-Silicon Substrates
ISSN: 2369 - 3355
Publisher: author
Osteoblast Behavior on Silicon and Porous-Silicon Substrates
Indexed in
Technology and Engineering
ARTICLE-FACTOR
1.3
Article Basics Score: 3
Article Transparency Score: 2
Article Operation Score: 2
Article Articles Score: 3
Article Accessibility Score: 2
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1802
Publisher: Lifescience Global Inc.
International Journal Address (IAA):
IAA.ZONE/2369108253355
eISSN
:
2369 - 3355
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Abstract
Osteoblast viability, proliferation, protein expression and mineralization were studied on bare, micro- and nanoporous silicon (Si) substrates. Micro- and nano-porous-Si substrates were prepared by anodic etching of silicon in ethanolic hydrofluoric acid and characterized using scanning electron and atomic force microscopies. Mouse osteoblasts were cultured on these substrates and cellular response to these surfaces was assessed using the Live/Dead Cell Viability assay and the MTT assay for cell proliferation. Osteoblast functionality was assessed using immunohistochemistry for bone protein specific markers. Osteoblasts grew well on micro- and nanoporous silicon substrates over the twenty-one day experimental period supporting the assessment that these are suitable cell supportive surfaces. Cell proliferation rates on bare and nanoporous silicon were similar initially, however, nanoporous silicon displayed enhanced cell proliferation,...
