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INVESTIGATING THE ESTROGENIC EFFECTS OF TEST ITEMS VIA ORAL ADMINISTRATION IN A FEMALE RAT OVARIECTOMY MODEL
ISSN: 2584 - 0290
Publisher: author
INVESTIGATING THE ESTROGENIC EFFECTS OF TEST ITEMS VIA ORAL ADMINISTRATION IN A FEMALE RAT OVARIECTOMY MODEL
Indexed in
Technology and Engineering
ARTICLE-FACTOR
1.3
Article Basics Score: 2
Article Transparency Score: 3
Article Operation Score: 3
Article Articles Score: 2
Article Accessibility Score: 3
SUBMIT PAPER ASK QUESTION
International Category Code (ICC):
ICC-1802
Publisher: Shree B.n.singh Lok Kalyan Shiksha Samiti
International Journal Address (IAA):
IAA.ZONE/2584417180290
eISSN
:
2584 - 0290
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Abstract
To evaluate the effects of estrogen and estrogenic compounds on cognition in ovariectomized rats. Female Albino wistar rats (3–5 months old) weighing 250–300 g were randomly divided into seven groups: Sham, ovariectomized (OVX), OVX plus estradiol valerate, OVX plus ipriflavone, OVX plus raloxifene, OVX plus tibolone, OVX plus low-dose estradiol valerate and ipriflavone. All treatments were given orally for 3 months; whereas the drug groups received indicated drugs, the Sham and OVX control groups received saline. The escape latency of rats was tested by the Morris water maze test and the expression of amyloid precursor protein (APP) in hippocampus was determined by reverse transcription polymerase chain reaction. The level of serum estradiol and the diameter of the endometrial gland and the thickness of endometrium were also evaluated. The latency of the OVX group was noticeably longer than that of the Sham group, and the latency of ...
